first pass metabolismの例文

• It also avoids first pass metabolism that occurs in ingested drugs.
• The primary metabolite is GZDV, an inactive metabolite produced after first pass metabolism.
• Loperamide should be administered with caution to people with liver failure due to reduced first pass metabolism.
• It is also increased if another drug competing with it in first pass metabolism is given concurrently.
• There is marked individual variation in the oral dose due to differences in the extent of first pass metabolism.
• These drug delivery options allow the medication to bypass the first pass metabolism thereby making the medication more bioavailable.
• When estrogen is ingested it is subjected to first pass metabolism ( Phase I drug metabolism ) and is processed through the liver.
• By mouth administration of naloxone blocks opioid action at the intestinal receptor level, but has low systemic bioavailability due to hepatic first pass metabolism.
• When corticosteroids are given in combination with praziquantel, cimetidine is also given, as corticosteroids decrease action of praziquantel by enhancing its first pass metabolism.
• As with PEA, NMPEA is metabolized relatively rapidly by monoamine oxidases during first pass metabolism; both compounds are preferentially metabolized by MAO-B.
• This first pass metabolism stimulates proteins associated with heart disease and stroke, such as C-reactive protein, activated protein C, and clotting factors.
• Efflux by P-glycoprotein in the intestinal wall reduces passage of loperamide, and the fraction of drug crossing is then further reduced through first pass metabolism by the liver.
• If the patient requires an oral dose, bioavailability will be less than 1 ( depending upon absorption, first pass metabolism etc . ), requiring a larger loading dose.
• Delivering analgesics by suppository has the advantage of avoiding first pass metabolism . ( No puns intended . ) [ Talk ] 19 : 04, 10 November 2008 ( UTC)
• In the body " O "-acetylpsilocin is first pass metabolism and during subsequent passes through the liver ( evident as psilacetin is also active via parenteral routes of ingestion ).
• When estrogen as estradiol is used transdermally as a patch, gel, or pessary with micronized progesterone this may avoid the serious side effects associated with oral estradiol HRT since this avoids first pass metabolism ( Phase I drug metabolism ).
• Researchers later found out that trifluridine, when taken orally, was broken down into the inactive metabolites 5-trifluoromethyluracil and 5-trifluoromethyl-2, 4 ( 1 " H ", 3, " H " )-pyrimidinedione ( FTY ) during its extensive first pass metabolism in the liver via the enzyme thymidine phosphorylase.
• Using a patch, gel, or pessary to take estrogen avoids first pass metabolism and the risks associated with it and the same level of blood concentration can be achieved avoiding the serious side effects associated with oral estradiol HRT . Current research shows that the transdermal route of estradiol administration can also be advantageous for women with diabetes, hypertension and other cardiovascular risk factors, as those risks increase with advancing age.